{"product_id":"kpv-peptide-5mg","title":"KPV Peptide (5MG)","description":"\u003cp\u003e\u003cstrong\u003eKPV\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBased on current research, here are the top 5 reported benefits of KPV (a tripeptide — Lysine-Proline-Valine — derived from α-MSH):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1. Gut inflammation \/ IBD suppor\u003c\/strong\u003et\u003cbr\u003eKPV is transported directly into intestinal cells via the PepT1 transporter, where it has significantly decreased inflammation in the colon and intestinal lining by inhibiting pro-inflammatory cytokine synthesis and secretion within intestinal epithelial cells. A landmark study in *Gastroenterology* found PepT1-mediated uptake of KPV significantly reduced intestinal inflammation in experimental models of colitis (Dalmasso et al., 2008).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e2. Systemic anti-inflammatory action\u003c\/strong\u003e\u003cbr\u003eKPV reduces inflammation by binding to melanocortin receptors (MC1R and MC3R), blocking the NF-κB pathway, and lowering the release of pro-inflammatory cytokines such as TNF-α and IL-6.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3. Skin conditions (eczema, psoriasis, acne, rosacea)\u003c\/strong\u003e\u003cbr\u003eIt's used for reducing flare-ups of eczema, psoriasis, and other inflammatory skin conditions, and topical formulations have shown promise in cosmetic dermatology for concerns such as acne, rosacea, and redness.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e4. Gut barrier \/ epithelial integrity\u003c\/strong\u003e\u003cbr\u003eBeyond just calming inflammation, it helps strengthen epithelial barriers in the gut and skin, with animal models showing improved mucosal integrity and reduced inflammatory activity after KPV exposure.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e5. Antimicrobial properties\u003c\/strong\u003e\u003cbr\u003eKPV offers therapeutic benefits largely centered around its anti-inflammatory and antimicrobial properties, which contributes to its use in both gut and skin applications.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Arielle Research Inc.","offers":[{"title":"5mg","offer_id":52427152228583,"sku":null,"price":80.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0605\/7105\/8407\/files\/KPV5mg.png?v=1785261544","url":"https:\/\/www.arielleresearch.com\/products\/kpv-peptide-5mg","provider":"Arielle Research Inc.","version":"1.0","type":"link"}