DSIP Delta Sleep-Inducing Peptide

The Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide that was first isolated in the 1970s and studied for its potential role in promoting deep (delta-wave) sleep. It is a small peptide composed of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu).

Key Information
Function: DSIP is primarily associated with sleep regulation and the modulation of the stress response system. It is believed to enhance slow-wave sleep (SWS) and normalize disturbed sleep patterns in some individuals.

Other Potential Effects: Beyond sleep, research (mostly preclinical) has explored DSIP's potential for:

• Reducing stress and anxiety by modulating the HPA axis and lowering cortisol levels.
• Providing pain relief (analgesic effects), potentially by interacting with opioid receptors.
• Treating withdrawal symptoms from alcohol and opiates, with some studies showing rapid improvement in patients.
• Neuroprotection and modulation of growth hormone release.
  

Mechanism: The exact mechanism by which DSIP works remains unclear, and no specific precursor peptide or receptor has been definitively identified. It may work by modulating neurotransmitters like GABA and affecting the body's endocrine system.